Will there be a cure for baldness in 2022?
In June 2022, the FDA approved the first treatment for a type of hair loss in which the immune system attacks hair follicles, known as alopecia areata. The drug, called baricitinib, was already approved for the treatment of another autoimmune disorder, rheumatoid arthritis.
What is SCUBE3 found in?
SCUBE3 (signal peptide CUB-EGF-like domain-containing protein 3) belongs to a newly identified secreted and cell membrane-associated SCUBE family, which is evolutionarily conserved in vertebrates. Scube3 is predominantly expressed in a variety of developing tissues in mice such as somites, neural tubes, and limb buds.
How does SCUBE3 work?
By activating stem cells present in people’s scalps, SCUBE3 hacks hair follicles to restart the production line and promote rapid growth. Plikus’ research began because he wanted to better understand dermal papilla cells, which are located at the bottom of hair follicles.